Endocrine Abstracts

Cancer cells show different metabolic requirements than normal cells, being the high rate of glucose uptake one of the most important aspects. An increase in glucose uptake has been associated mainly with GLUT1 overexpression but may also involve other transporters including GLUT4, whose presence in prostate cancer cells was recently discovered in our laboratory. Moreover, androgens stimulate anabolic synthesis and increase glucose uptake. Despite this, the regulation of GLUT ...

Objective: To describe the clinical, aetiological and prognostic differences in diabetic and non-diabetic ischaemic stroke (IS) patients.Materials and methods: Retrospective analysis of prospective series of IS patients. Patients were classified as non-DM and DM patients. Demographic and clinical characteristics were compared between two groups. IS prognosis was evaluated by modified Rankin scale (mRS) and NIHSS (NIH stroke scale)....

The medical and social importance of a problem of a gestational diabetes (GD) is caused by higher probability of occurrence of the complicated current of pregnancy and delivery. Frequency of a GD varies within 1.5–13% from total pregnancies, essentially increasing in risk groups.Materials and methods: One hundred and fifty-six pregnant women in different periods of gestation were examined. The estimation of GD’s risk factors was spent to all wo...

Nuclear corepressor 1 (NCoR) associates with nuclear receptors and other transcription factors leading to transcriptional repression. Genomic studies have shown the presence of inactivating mutations of the NCoR gene in human tumours and we have found that NCoR depletion with siRNA in hepatocarcinoma SK-hep1 cells enhances invasion, tumour growth and metastasis in nude mice, while expression of the thyroid hormone receptor β (TRβ) increases NCoR levels, repr...

Introduction: Diabetes Mellitus (DM) and prediabetic states (pre-DM) are well known risk factors for stroke. Admission blood glucose level and its control during hospital stay, help predicting arterial recanalization after thrombolysis and middle and long term prognosis. We analysed recurrence, mortality and nosocomial infectious complications in DM, pre-DM and patients without previous or newly diagnosed DM or pre-DM.Methods: Descriptive analysis in con...

Reduced expression or activity of the thyroid hormone receptors (TRs) are common events in cancer, suggesting that these receptors could act as tumor suppressors. We have previously shown that TRβ expression in SK-hep1 hepatocarcinoma cells (SK-TRβ cells), reduces tumor growth and strikingly inhibits invasion, extravasation, and metastasis formation in nude mice. These effects could be related to a decreased expression in these cells of prometastatic genes, such as C...

Fibrosis represents a major health concern and presently has no successful treatment. Chronic liver fibrosis leads to portal hypertension, cirrhosis, hepatocellular carcinoma and liver failure. Transforming growth factor β (TGFβ), the main profibrogenic factor, mediates its actions mainly through activation of Smad transcription factors. We have previously observed a cross-talk between the thyroid hormone receptors (TRs) and the TGFβ pathway by which the thyroid...

Transforming growth factor beta (TGFβ), which plays a key role in cancer and fibrotic disorders, mediates its actions mainly through activation of Smad transcription factors, which bind to Smad Binding Elements (SBEs) in target genes. We have previously observed that the thyroid hormone T3 blocks transactivation of SBE-containing reporter plasmids by TGFβ, and represses transcription of endogenous TGFβ target genes. We have now analysed the thyroid ho...

Transforming growth factor β (TGFβ) signals through activation of Smad transcription factors, which bind to Smad binding elements (SBEs) in target genes. TGFβ can promote cancer cell proliferation and invasion, and plays a key role in the pathogenesis of scleroderma and other fibrotic disorders. We have previously shown that the thyroid hormone receptors (TRs) can block tumor growth and invasion. We now have analyzed the possibility that TRs could antagonize TGF...

Craniopharyngiomas are rare benign epithelial tumors derived from remains of Rathke’s pouch. They are more prevalent in childhood, adolescence, and adults <50 years, and, commonly, are usually diagnosed after being associated with serious comorbidities when the development of the tumor is already advanced. To date, first-line therapy is usually surgery, but frequently the resection is not complete, causing high rates of recurrence. Therefore, the identification of ne...